Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity.However, its role in memory formation in the amygdala, a site critical for the formation of fear memories, currently remains unknown.Here we provide the first evidence that protein degradation through the UPS is critically en
Heterozygous loss-of-function mutation of the calcium sensing-receptor (CaSR), causes familial hypocalciuric hypercalcemia type 1 (FHH1), a typically benign condition characterized by mild hypercalcemia.In contrast, homozygous mutation of this dimer-forming G-protein coupled receptor manifests as the lethal neonatal severe hyperparathyroidism (NSHP
This paper addresses the upset prediction problem of friction welded joints.Based on finite Foot Print Magnet Kit element simulations of inertia friction welding (IFW), a radial basis function (RBF) neural network was developed initially to predict the final upset for a number of welding parameters.The predicted joint upset by the RBF neural networ
The article carries out an analysis of the competitiveness of the Russian space industry in the international space services market according to the following indicators: the volume of budget of national space organizations, the volume of the commercial space exploration market, Horse Girths the number of space launches, positions in manned cosmona
This article examines how literature is a networked social space of political repression and resistance, refracting broader contestations over national sovereignty, self-determination, and identity.Politicizing the traditionally apolitical “world of letters” Foot Print Magnet Kit in Habermas’s Structural Transformation of the Public Sphere ,